Dr Fernando Zampieri MD PhD published a thought provoking article in ICU management and practice. This takes an example of use of CRP in diagnosing ventilator associated pneumonia and various clinician biases. In the end, there is an exhaustive list of things which we do today which are not proven to be beneficial.
Continuous infusion of beta-lactam antibiotics improves mortality in sepsis
Reference https://jamanetwork.com/journals/jama/fullarticle/2819971